ホームページ MAPK Mixed Lineage Kinase MLK3 阻害剤
  • MLKL
  • MLK1
  • MLK2
  • MLK3

MLK3 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S7343 URMC-099 URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. URMC-099 also inhibits ABL1 with IC50 of 6.8 nM. URMC-099 induces autophagy. Pan MLK3, IC50: 14 nM