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LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. For animal testing, the water-soluble
![](https://www.selleckchem.</td>
<td >Pan</td>
<td>ALK1, IC50: 0.8 nM</td>
</tr>
<tr>
<td>S7359</td>
<td><a href="/products/k02288.html">K02288</a></td>
<td>K02288 is a potent, and selective type I BMP receptor inhibitor with <b>IC50</b> of 1.1, 1.8, 6.4 nM for <b>ALK2</b>, <b>ALK1</b> and <b>ALK6</b>, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.</td>
<td >Pan</td>
<td>ALK1, IC50: 1.8 nM</td>
</tr>
<tr>
<td>S7147</td>
<td><a href="/products/ldn-212854.html">LDN-212854 </a></td>
<td>LDN-212854 (BMP Inhibitor III) is a potent and selective <b>BMP receptor</b> inhibitor with </b>IC50</b> of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.</td>
<td >Pan</td>
<td>ALK1, IC50: 2.4 nM</td>
</tr>
<tr>
<td>S7148</td>
<td><a href="/products/ml347.html">ML347</a></td>
<td>ML347 (LDN-193719) is a selective <b>BMP receptor</b> inhibitor with <b>IC50</b> of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with <b>IC50</b> of 46 nM.</td>
<td >Pan</td>
<td>ALK1, IC50: 46 nM</td>
</tr>
</tbody>
</table>
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