SIK

亜型選択性的な製品

SIK1 SIK2 SIK3

SIK製品

All (6)
SIK阻害剤 (6)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7565	WH-4-023	WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.	Nat Commun, 2024, 15(1):668 Mol Cell, 2024, 84(14):2665-2681.e13 Cell Mol Life Sci, 2024, 81(1):427
S9646	YKL-05-099	YKL-05-099 is an inhibitor of salt-inducible kinase (SIK) with IC50 of ~10 nM, ~40 nM and ~30 nM for SIK1, SIK2 and SIK3, respectively.	Oncogenesis, 2022, 11(1):18 Int J Hematol, 2020, 10.1007/s12185-020-03026-1
S8543	ARN-3236	ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.	Int J Biol Sci, 2024, 20(1):312-330 Mol Oncol, 2022, 16(13):2558-2574
S8393	HG-9-91-01	HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective inhibitor of salt-inducible kinase (SIK) with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3, respectively.	bioRxiv, 2023, 10.1101/2023.04.05.535731 Int J Hematol, 2020, 10.1007/s12185-020-03026-1
S0051	YKL 06-061	YKL 06-061 is a potent and selective salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.
E1997^New	GLPG3970	GLPG3970 (compound 32) is a dual inhibitor of SIK2 and SIK3, with IC50 of 282.8 nM, 7.8 nM and 3.8 nM for SIK1, SIK2 and SIK3, respectively. It has the potential to treat autoimmune and inflammatory diseases.
S7565	WH-4-023	WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.	Nat Commun, 2024, 15(1):668 Mol Cell, 2024, 84(14):2665-2681.e13 Cell Mol Life Sci, 2024, 81(1):427
S9646	YKL-05-099	YKL-05-099 is an inhibitor of salt-inducible kinase (SIK) with IC50 of ~10 nM, ~40 nM and ~30 nM for SIK1, SIK2 and SIK3, respectively.	Oncogenesis, 2022, 11(1):18 Int J Hematol, 2020, 10.1007/s12185-020-03026-1
S8543	ARN-3236	ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.	Int J Biol Sci, 2024, 20(1):312-330 Mol Oncol, 2022, 16(13):2558-2574
S8393	HG-9-91-01	HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective inhibitor of salt-inducible kinase (SIK) with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3, respectively.	bioRxiv, 2023, 10.1101/2023.04.05.535731 Int J Hematol, 2020, 10.1007/s12185-020-03026-1
S0051	YKL 06-061	YKL 06-061 is a potent and selective salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.
E1997^New	GLPG3970	GLPG3970 (compound 32) is a dual inhibitor of SIK2 and SIK3, with IC50 of 282.8 nM, 7.8 nM and 3.8 nM for SIK1, SIK2 and SIK3, respectively. It has the potential to treat autoimmune and inflammatory diseases.
E1997^New	GLPG3970	GLPG3970 (compound 32) is a dual inhibitor of SIK2 and SIK3, with IC50 of 282.8 nM, 7.8 nM and 3.8 nM for SIK1, SIK2 and SIK3, respectively. It has the potential to treat autoimmune and inflammatory diseases.

SIK阻害剤の選択性比較

Tags: SIK inhibitor|SIK agonist|SIK activator|SIK inducer|SIK antagonist|SIK signaling pathway|SIK assay kit