Pyroptosis

亜型選択性的な製品

Gasdermin

Pyroptosis製品

All (5)
Pyroptosis阻害剤 (4)
Pyroptosis活性剤(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1680	Disulfiram	Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).	Bioact Mater, 2024, 36:238-255 Cell Death Dis, 2023, 14(12):825 J Transl Med, 2023, 21(1):334
S9302	Polyphyllin VI	Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.	Redox Biol, 2024, 70:103039 Int J Oral Sci, 2024, 16(1):3 bioRxiv, 2024, 2024.03.19.585812
S9817	Ac-FLTD-CMK	Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.	Biomolecules, 2022, 12(11)1660
S9622	LDC7559	LDC7559 is a potent Gasdermin D(GSDMD) inhibitor inhibiting the pyroptosis and lessens its inflammation.	iScience, 2024, 27(5):109774 Heliyon, 2024, 10(11):e32571
S5465	Morroniside	Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption.
S1680	Disulfiram	Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).	Bioact Mater, 2024, 36:238-255 Cell Death Dis, 2023, 14(12):825 J Transl Med, 2023, 21(1):334
S9817	Ac-FLTD-CMK	Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.	Biomolecules, 2022, 12(11)1660
S9622	LDC7559	LDC7559 is a potent Gasdermin D(GSDMD) inhibitor inhibiting the pyroptosis and lessens its inflammation.	iScience, 2024, 27(5):109774 Heliyon, 2024, 10(11):e32571
S5465	Morroniside	Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption.
S9302	Polyphyllin VI	Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.	Redox Biol, 2024, 70:103039 Int J Oral Sci, 2024, 16(1):3 bioRxiv, 2024, 2024.03.19.585812

Pyroptosis阻害剤の選択性比較

Tags: Pyroptosis inhibitor|Pyroptosis agonist|Pyroptosis activator|Pyroptosis inducer|Pyroptosis antagonist|Pyroptosis signaling pathway|Pyroptosis assay kit