Ampicillin Trihydrate

Ampicillin Trihydrate (500 mg) results in rapid bactericidal effect for SP34, the concentrations declines to the limit of detection (100 CFU/mL) during the initial 6 hours, and regrowth is not observed over the remaining 18 hours. ^[1]

Ampicillin Trihydrate (10 mg/kg) results in half life (t _1/2) of 1.2 hours in goats and 2.48 hours in sheep, clearance (Cl) of 2921 mL/h·kg in goats and 262 mL/h·kg in sheep, ampicillin volume of distribution (Vdarea) of 5673 mL/kg in goats and 992 mL/kg in sheep. ^[2] Ampicillin Trihydrate (0.18 kg/kg-3 kg/kg) results in no dose-related mortality, normal body weights, no compound-related gross or histopathologic lesions and diarrhea in mice and rats. ^[3] Ampicillin in combination of norfloxacin, at a dose of 1g/L, maximally suppresses the numbers of cecal aerobic and anaerobic bacteria in ob/ob mice. Ampicillin in combination of norfloxacin results in a significant improvement in fasting glycemia and oral glucose tolerance reduced liver triglycerides and increased liver glycogen and concomitant reduction of plasma lipopolysaccharides in ob/ob mice. ^[4] Ampicillin trihydrate (20 mg/kg) treats five foals, the mean peak serum ampicillin concentration at two to three days old is 5.0 μg/mL at 1 hours after treatment, the mean peak serum concentration at 16 days to 21 days old is 2.7 μg/mL at 2 hours, the concentrations steadily declines and ampicillin is not detected in the serum from any of the foals by 24 hours, and serum clearance averages 17.7 mL/min/kg at two to three days and 35.8 mL/min/kg at 16 days to 21 days. ^[5]