Phosphorylase

Phosphorylase製品

All (6)
Phosphorylase阻害剤 (5)
Phosphorylase活性剤(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S2717	CP-91149	CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.	Nat Commun, 2024, 15(1):1524 EMBO Rep, 2024, 10.1038/s44319-024-00278-4 Cell Rep, 2023, 42(6):112578
S2045	Doxifluridine	Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU).	Acta Histochem, 2022, 124(4):151895 Cell Metab, 2019, 29(5):1217-1231 Oncotarget, 2018, Oncotarget
S3731	Tipiracil hydrochloride	Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.	Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9 JCI Insight, 2022, 7(22e158060)
S0031	Ingliforib	Ingliforib (CP 368296) is a glycogen phosphorylase (GP) inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
S6510	Iso-H7 dihydrochloride	Iso-H7 dihydrochloride is an inhibitor of phosphokinase C.
E6031^New	Tipiracil	Tipiracil [TPI (freebase)] is a potent inhibitor of thymidine phosphorylase. It increases exposure to its co-administered drug by inhibiting its metabolism through thymidine phosphorylase, enhancing its therapeutic effects and is used as adjunct therapy for certain gastric and colorectal cancers.
S2717	CP-91149	CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.	Nat Commun, 2024, 15(1):1524 EMBO Rep, 2024, 10.1038/s44319-024-00278-4 Cell Rep, 2023, 42(6):112578
S3731	Tipiracil hydrochloride	Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.	Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9 JCI Insight, 2022, 7(22e158060)
S0031	Ingliforib	Ingliforib (CP 368296) is a glycogen phosphorylase (GP) inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
S6510	Iso-H7 dihydrochloride	Iso-H7 dihydrochloride is an inhibitor of phosphokinase C.
E6031^New	Tipiracil	Tipiracil [TPI (freebase)] is a potent inhibitor of thymidine phosphorylase. It increases exposure to its co-administered drug by inhibiting its metabolism through thymidine phosphorylase, enhancing its therapeutic effects and is used as adjunct therapy for certain gastric and colorectal cancers.
S2045	Doxifluridine	Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU).	Acta Histochem, 2022, 124(4):151895 Cell Metab, 2019, 29(5):1217-1231 Oncotarget, 2018, Oncotarget
E6031^New	Tipiracil	Tipiracil [TPI (freebase)] is a potent inhibitor of thymidine phosphorylase. It increases exposure to its co-administered drug by inhibiting its metabolism through thymidine phosphorylase, enhancing its therapeutic effects and is used as adjunct therapy for certain gastric and colorectal cancers.

Phosphorylase阻害剤の選択性比較