Tirzepatide (LY3298176) sodium

製品コード：P1206 純度：99.96%

Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) sodium is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.

Amino-acid Sequence

CAS No. 2023788-19-2 (free base)

サイズ	価格(税別)	在庫状況
1mg	JPY 44500	国内在庫あり
5mg	JPY 119500	国内在庫あり
25mg	JPY 296500	国内在庫あり
バルクサイズ	バルク特価あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

製品安全説明書

現在のバッチを見る：純度： 99.96%

99.96

化学情報

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			1个月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (20.77 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Ethanol : 3 mg/mL

Water : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

生物活性

製品説明

Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.

Targets

GLP-1 receptor	GIP receptor
18.1 nM	18.2 nM

In vitro
In vitro	In HEK293 cells, Tirzepatide induces internalization of the GIPR and has a propensity toward partial agonism, and this ultimately reflects in signaling bias toward the cAMP pathway versus β-arrestin recruitment.^[1]

In Vivo
In vivo	LY3298176 shows glucose-dependent insulin secretion and improves glucose tolerance by acting on both GIP and GLP-1 receptors in mice. Chronic treatment with LY3298176 results in a significant dose-dependent decrease in body weight that is more pronounced than that observed with semaglutide.^[2]

参考
[1] Francis S Willard, et al. JCI Insight. 2020 Sep 3;5(17):e140532. [2] Coskun T, et al. Mol Metab. 2018 Dec;18:3-14.

参考

製品情報

Molecular Formula	C₂₂₅H₃₄₈N₄₈O₆₈• XNa
Molecular Weight	4813.45
CAS No.	2023788-19-2 (free base)
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)