GsMTx4

製品コード：P1205 純度：99.08%

GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs).

Amino-acid Sequence

CAS No. 1209500-46-8

サイズ	価格(税別)	在庫状況
1mg	JPY 79300	国内在庫あり
5mg	JPY 238000	国内在庫あり
25mg	JPY 715000	お問い合わせ
バルクサイズ	バルク特価あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

製品安全説明書

現在のバッチを見る： P120502 Water] 82 mg/mL] false] ] ] false] ] ] false 純度： 99.08%

99.08

化学情報

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			１ケ月-20°Cin solvent

In vitro
Batch:

Water : 82 mg/mL

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

生物活性

製品説明

GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs).

Targets

MSCs

In vitro
In vitro	Pretreatment of GsMTx4 and BAPTA-AM suppress the Yoda1-induced accumulation of HIF-1alpha, NFATC1, and NFATC3 proteins and also suppress Yoda1-induced VEGF-A expression at the mRNA and protein levels.^[2]
細胞実験	細胞株	BMDMs, RAW264.7 cells
	濃度	5, 10 µM
	反応時間	30 min
	実験の流れ	To study the effect of mechanical stretching, BMDMs or RAW264.7 cells were treated with Yoda1, with or without pretreatment with inhibitors for 30 min. The inhibitors included cyclosporin A, FK506, echinomycin, GsMTx4, BAPTA-AM and RN-1734. In some experiments, BMDMs were treated with GSK1016790A. (Data sourced from selleck products)

参考
[1] Radhakrishnan Gnanasambandam, et al. Biophys J. 2017 Jan 10;112(1):31-45. [2] Zhang X, et al. Theranostics. 2022 Jan 16;12(4):1621-1638. [3] Liu Z, et al. Biochem Biophys Res Commun. 2022 Nov 21;638:140-146. [4] Xu H, et al. FASEB J. 2022 Aug;36(8):e22423. + 展開

参考

[4] Xu H, et al. FASEB J. 2022 Aug;36(8):e22423.

+ 展開

製品情報

Molecular Formula	C₁₈₅H₂₇₃N₄₉O₄₅S₆
Molecular Weight	4095.86
CAS No.	1209500-46-8
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)