Bulevirtide (Myrcludex B)

製品コード：P1105 純度：99.89%

Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.

Amino-acid Sequence

CAS No. 2012558-47-1

サイズ	価格(税別)	在庫状況
5mg	JPY 74800	国内在庫あり
25mg	JPY 224500	国内在庫あり
100mg	JPY 448500	国内在庫なし(納期7~10日)
バルクサイズ	バルク特価あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

製品安全説明書

現在のバッチを見る：純度： 99.89%

99.89

化学情報

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			１ケ月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (18.52 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : 50 mg/mL

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

生物活性

製品説明

Targets

NTCP

∼80 pM

In vitro
In vitro	Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt. transport.
細胞実験	細胞株	U2OS cells
	濃度	200 nM
	反応時間	1 h
	実験の流れ	Cells were treated with indicated concentration of drug for 1 h.

参考
[1] Stephan Urban, et al. Gastroenterology . 2014 Jul;147(1):48-64. [2] Donkers JM, et al. JHEP Rep. 2019 Aug 1;1(4):278-285.

参考

製品情報

Molecular Formula	C248H355N65O72
Molecular Weight	5398.86
CAS No.	2012558-47-1
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)