NKCC

NKCC製品

All (5)
NKCC阻害剤 (5)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S8615	DCA (Sodium dichloroacetate)	DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na⁺-K⁺-2Cl^- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.	Cell Mol Life Sci, 2024, 81(1):324 Free Radic Biol Med, 2024, 224:39-49 iScience, 2024, 27(1):108645
S1603	Furosemide	Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.	J Immunother Cancer, 2024, 12(11)e009805 Ren Fail, 2022, 44(1):1345-1355 Environ Toxicol Chem, 2021, 10.1002/etc.5018
S1287	Bumetanide	Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure.	J Immunother Cancer, 2024, 12(11)e009805 PLoS Pathog, 2024, 20(10):e1012601 Cancer Med, 2024, 13(11):e7291
S5194	Furosemide sodium	Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.	Nat Commun, 2024, 15(1):7342 Ren Fail, 2022, 44(1):1345-1355
E2358	Azosemide	Azosemide is a potent Na⁺–K⁺–2Cl⁻ cotransporter NKCC1 inhibitor with IC50s of 0.246 µM for hNKCC1A and 0.197 µM for NKCC1B, respectively.
S8615	DCA (Sodium dichloroacetate)	DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na⁺-K⁺-2Cl^- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.	Cell Mol Life Sci, 2024, 81(1):324 Free Radic Biol Med, 2024, 224:39-49 iScience, 2024, 27(1):108645
S1603	Furosemide	Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.	J Immunother Cancer, 2024, 12(11)e009805 Ren Fail, 2022, 44(1):1345-1355 Environ Toxicol Chem, 2021, 10.1002/etc.5018
S1287	Bumetanide	Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure.	J Immunother Cancer, 2024, 12(11)e009805 PLoS Pathog, 2024, 20(10):e1012601 Cancer Med, 2024, 13(11):e7291
S5194	Furosemide sodium	Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.	Nat Commun, 2024, 15(1):7342 Ren Fail, 2022, 44(1):1345-1355
E2358	Azosemide	Azosemide is a potent Na⁺–K⁺–2Cl⁻ cotransporter NKCC1 inhibitor with IC50s of 0.246 µM for hNKCC1A and 0.197 µM for NKCC1B, respectively.

NKCC阻害剤の選択性比較