FTO

FTO製品

All (6)
FTO阻害剤 (6)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S8837	FB23-2	FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits FTO's N⁶-methyladenosine (m⁶A) demethylase activity with IC50 of 2.6 μM.	Nat Commun, 2024, 15(1):9559 J Exp Clin Cancer Res, 2023, 42(1):217 Cell Death Discov, 2023, 9(1):457
S4295	Meclofenamate Sodium	Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.	Adv Sci (Weinh), 2023, e2307206. Int J Mol Sci, 2023, 24(2)1624 Gynecol Endocrinol, 2023, 10.1080/09513590.2023.2276167
S2400	Rheic Acid	Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N⁶-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.	Animals (Basel), 2024, 14(16)2434 Cell Chem Biol, 2016, 23(3):415-25
S9876	Dac51	Dac51 is a potent FTO inhibitor with an IC50 of 0.4 μM for inhibiting FTO demethylation.	Int J Mol Sci, 2023, 24(9)7957
S6291	FB23	FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.	Oncogene, 2022, 41(20):2860-2872
S9946	Bisantrene (CS1)	Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity. Bisantrene also is a potent and selective FTO inhibitor.
S8837	FB23-2	FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits FTO's N⁶-methyladenosine (m⁶A) demethylase activity with IC50 of 2.6 μM.	Nat Commun, 2024, 15(1):9559 J Exp Clin Cancer Res, 2023, 42(1):217 Cell Death Discov, 2023, 9(1):457
S4295	Meclofenamate Sodium	Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.	Adv Sci (Weinh), 2023, e2307206. Int J Mol Sci, 2023, 24(2)1624 Gynecol Endocrinol, 2023, 10.1080/09513590.2023.2276167
S2400	Rheic Acid	Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N⁶-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.	Animals (Basel), 2024, 14(16)2434 Cell Chem Biol, 2016, 23(3):415-25
S9876	Dac51	Dac51 is a potent FTO inhibitor with an IC50 of 0.4 μM for inhibiting FTO demethylation.	Int J Mol Sci, 2023, 24(9)7957
S6291	FB23	FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.	Oncogene, 2022, 41(20):2860-2872
S9946	Bisantrene (CS1)	Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity. Bisantrene also is a potent and selective FTO inhibitor.

FTO阻害剤の選択性比較