cAMP

cAMP製品

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• cAMP阻害剤 (10)
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• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2449	Forskolin (Colforsin)	コルホルチン (Forskolin (Colforsin)) は、広範な細胞腫における真核生物のアデニル酸シクラーゼ (adenylate cyclase, AC) の遍在する活性化因子であり、細胞生理学の研究において cAMP のレベルを上げるために一般的に使用されています。ホルスコリン (Forskolin) は、PXR と FXR も活性化します。 ホルスコリンはオートファジー (autophagy) を刺激します。	Circulation, 2024, 149(18):1435-1456 Cell Stem Cell, 2024, S1934-5909(24)00048-1 iScience, 2024, 27(2):108857
S8283	SQ22536	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.	J Nanobiotechnology, 2024, 22(1):85 Invest Ophthalmol Vis Sci, 2024, 65(3):10 Kaohsiung J Med Sci, 2023, 10.1002/kjm2.12722
S7499	ESI-09	ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.	J Biol Chem, 2023, 299(6):104749 J Biol Chem, 2023, 299(6):104749 Drug Dev Res, 2021, 10.1002/ddr.21901
S8415	PACAP 1-38	PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.	Biomed Pharmacother, 2024, 179:117427 Invest Ophthalmol Vis Sci, 2022, 63(3):18 Front Immunol, 2021, 12:714244
S4552	Bithionol	Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.	iScience, 2023, 10.1016/j.isci.2023.106661 Cancer Lett, 2020, 479:100-111 Inflammation, 2019, 42(5):1530-1541
S8416	PACAP 6-38 acetate	PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.	Front Immunol, 2021, 12:714244
S7500	HJC0350	HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.	J Mol Cell Biol, 2019, 11(5):395-407
A2385	Zelminemab (Anti-PAC1)	Zelminemab (AMG-301) is a human monoclonal antibody that inhibits the PACAP type I (PAC1) receptor. MW: 145.5 kD.
S3382	ESI-05	ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation.
S8414	PACAP 1-27	Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
S0837	HJC0197	HJC0197 is a selective Epac1/2 dual antagonists with an IC50 of 5.9 μM for Epac2.
S6850	NE 52-QQ57	NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).	Exp Hematol Oncol, 2024, 13(1):13
S6478	Fipexide hydrochloride	Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
S0451	ST034307	ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
S8415	PACAP 1-38	PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.	Biomed Pharmacother, 2024, 179:117427 Invest Ophthalmol Vis Sci, 2022, 63(3):18 Front Immunol, 2021, 12:714244
S8283	SQ22536	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.	J Nanobiotechnology, 2024, 22(1):85 Invest Ophthalmol Vis Sci, 2024, 65(3):10 Kaohsiung J Med Sci, 2023, 10.1002/kjm2.12722
S7499	ESI-09	ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.	J Biol Chem, 2023, 299(6):104749 J Biol Chem, 2023, 299(6):104749 Drug Dev Res, 2021, 10.1002/ddr.21901
S4552	Bithionol	Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.	iScience, 2023, 10.1016/j.isci.2023.106661 Cancer Lett, 2020, 479:100-111 Inflammation, 2019, 42(5):1530-1541
S8416	PACAP 6-38 acetate	PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.	Front Immunol, 2021, 12:714244
S7500	HJC0350	HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.	J Mol Cell Biol, 2019, 11(5):395-407
S3382	ESI-05	ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation.
S8414	PACAP 1-27	Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
S6850	NE 52-QQ57	NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).	Exp Hematol Oncol, 2024, 13(1):13
S6478	Fipexide hydrochloride	Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
S0451	ST034307	ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
A2385	Zelminemab (Anti-PAC1)	Zelminemab (AMG-301) is a human monoclonal antibody that inhibits the PACAP type I (PAC1) receptor. MW: 145.5 kD.
S2449	Forskolin (Colforsin)	コルホルチン (Forskolin (Colforsin)) は、広範な細胞腫における真核生物のアデニル酸シクラーゼ (adenylate cyclase, AC) の遍在する活性化因子であり、細胞生理学の研究において cAMP のレベルを上げるために一般的に使用されています。ホルスコリン (Forskolin) は、PXR と FXR も活性化します。 ホルスコリンはオートファジー (autophagy) を刺激します。	Circulation, 2024, 149(18):1435-1456 Cell Stem Cell, 2024, S1934-5909(24)00048-1 iScience, 2024, 27(2):108857
S0837	HJC0197	HJC0197 is a selective Epac1/2 dual antagonists with an IC50 of 5.9 μM for Epac2.
S8415	PACAP 1-38	PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.	Biomed Pharmacother, 2024, 179:117427 Invest Ophthalmol Vis Sci, 2022, 63(3):18 Front Immunol, 2021, 12:714244