BMI-1

BMI-1製品

All (5)
BMI-1阻害剤 (5)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7372	PTC-209	PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).	Front Nutr, 2023, 10:1141964 bioRxiv, 2023, 2023.01.23.525196 Int J Biol Sci, 2022, 18(7):2807-2820
S7539	PTC-209 HBr	PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).	Nat Commun, 2023, 10.1038/s41467-023-42930-y Int J Biol Sci, 2022, 18(7):2807-2820 PLoS Pathog, 2022, 18(8):e1010801
S5315	PRT4165	PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro.	Nat Commun, 2023, 10.1038/s41467-023-42930-y Leukemia, 2021, 10.1038/s41375-021-01121-8 Leukemia, 2021, 10.1038/s41375-021-01121-8
S8820	Unesbulin (PTC596)	Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.	NPJ Precis Oncol, 2024, 8(1):68 PLoS One, 2023, 18(2):e0277313 bioRxiv, 2023, 2023.01.23.525196
S8662	PTC-028	PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification.	NPJ Precis Oncol, 2024, 8(1):68
S7372	PTC-209	PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).	Front Nutr, 2023, 10:1141964 bioRxiv, 2023, 2023.01.23.525196 Int J Biol Sci, 2022, 18(7):2807-2820
S7539	PTC-209 HBr	PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).	Nat Commun, 2023, 10.1038/s41467-023-42930-y Int J Biol Sci, 2022, 18(7):2807-2820 PLoS Pathog, 2022, 18(8):e1010801
S5315	PRT4165	PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro.	Nat Commun, 2023, 10.1038/s41467-023-42930-y Leukemia, 2021, 10.1038/s41375-021-01121-8 Leukemia, 2021, 10.1038/s41375-021-01121-8
S8820	Unesbulin (PTC596)	Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.	NPJ Precis Oncol, 2024, 8(1):68 PLoS One, 2023, 18(2):e0277313 bioRxiv, 2023, 2023.01.23.525196
S8662	PTC-028	PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification.	NPJ Precis Oncol, 2024, 8(1):68

BMI-1阻害剤の選択性比較

Tags: BMI-1 inhibitor | BMI-1 modulator | BMI-1 chemical