Actin

Actin製品

All (9)
Actin阻害剤 (8)
Actinモジュレータ(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S7497	CK-636	CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.	Elife, 2021, 10e65910 Theranostics, 2019, 9(25):7628-7647 Front Cell Infect Microbiol, 2017, 7:400
S8184	Cytochalasin D	Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap.	Cell Prolif, 2024, e13728. Nat Commun, 2023, 14(1):7576 Adv Sci (Weinh), 2023, 10(7):e2205566
S5256	Benproperine phosphate	Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of actin polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.	Mol Oncol, 2020, 10.1002/1878-0261.12854
E1042	SMIFH2	SMIFH2 is a specific inhibitor of formin that inhibits formin-driven actin polymerization in vitro with IC50s ranging from 5 to 15 μM for different formins.
S6673	CCG-222740	CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
E0076	Simufilam dihydrochloride	Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
E2956	Cytochalasin C	Cytochalasin C is a cell-permeable fungal metabolite that has been found in C. globosum. Cytochalasin C is an inhibitor of actin polymerization. It induces the formation of nuclear rodlets.
S3206	5a-Pregnane-3,20-dione	5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
S7690	CK-666	CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex with IC50 of 17 μM and 5 μM for BtArp2/3 complex and SpArp2/3 complex, respectively.	Res Sq, 2023, rs.3.rs-3372987
S7497	CK-636	CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.	Elife, 2021, 10e65910 Theranostics, 2019, 9(25):7628-7647 Front Cell Infect Microbiol, 2017, 7:400
S8184	Cytochalasin D	Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap.	Cell Prolif, 2024, e13728. Nat Commun, 2023, 14(1):7576 Adv Sci (Weinh), 2023, 10(7):e2205566
S5256	Benproperine phosphate	Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of actin polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.	Mol Oncol, 2020, 10.1002/1878-0261.12854
E1042	SMIFH2	SMIFH2 is a specific inhibitor of formin that inhibits formin-driven actin polymerization in vitro with IC50s ranging from 5 to 15 μM for different formins.
S6673	CCG-222740	CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
E2956	Cytochalasin C	Cytochalasin C is a cell-permeable fungal metabolite that has been found in C. globosum. Cytochalasin C is an inhibitor of actin polymerization. It induces the formation of nuclear rodlets.
S3206	5a-Pregnane-3,20-dione	5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
S7690	CK-666	CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex with IC50 of 17 μM and 5 μM for BtArp2/3 complex and SpArp2/3 complex, respectively.	Res Sq, 2023, rs.3.rs-3372987
E0076	Simufilam dihydrochloride	Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.

Actin阻害剤の選択性比較