DNA alkylator

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DNA alkylator製品

• All (16)
• DNA alkylator阻害剤 (3)
• DNA alkylator活性剤(1)
• DNA alkylatorモジュレータ(2)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1224	Oxaliplatin	Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Mol Cancer, 2024, 23(1):186 Mol Cancer, 2024, 23(1):23 Gastroenterology, 2024, S0016-5085(24)00062-3
S1215	Carboplatin	Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Commun, 2024, 15(1):1158 Cell Rep Med, 2024, S2666-3791(24)00201-5
S2057	Cyclophosphamide Monohydrate	Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.	BMC Cancer, 2024, 24(1):185 Nat Commun, 2023, 14(1):7576 EMBO Mol Med, 2023, 15(12):e18199
S1312	STZ (Streptozotocin)	STZ (Streptozotocin) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are unstable and should be fresh-prepared.	Cell Commun Signal, 2024, 22(1):368 Fluids Barriers CNS, 2024, 21(1):26 CNS Neurosci Ther, 2024, 30(8):e14913
S1692	Busulfan	Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.	J Immunother Cancer, 2024, 12(11)e009805 Nat Commun, 2022, 13(1):6110 Blood Cancer Discov, 2022, 3(2):154-169
S1302	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.	Cancer Res, 2023, 83(16):2750-2762 Comput Struct Biotechnol J, 2023, 21:3827-3840 Comput Struct Biotechnol J, 2023, 21:3827-3840
S1278	Altretamine	Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S8056	Lomeguatrib	Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.	Sci Rep, 2024, 14(1):12363 Neurooncol Adv, 2024, 6(1):vdad165 Int J Mol Sci, 2023, 24(20)15179
S3658	O6-Benzylguanine	O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.	Nat Commun, 2023, 14(1):5913 Nat Commun, 2023, 14(1):5913 Neuro Oncol, 2021, 23(6):920-931
E0609	Methyl methanesulfonate	Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.	Int J Biol Sci, 2024, 20(11):4513-4531 Cell Rep, 2024, 43(2):113779 J Transl Med, 2023, 21(1):183
S8880	Lobaplatin (D-19466)	Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Int J Nanomedicine, 2024, 19:9503-9547 Biochem Pharmacol, 2020, 12:114023
S6984	Dianhydrogalactitol (VAL-083)	Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.
S4447	Pipobroman	Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6958	Treosulfan	Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.
S7829	Tretazicar (CB1954)	Tretazicar (CB1954) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.	Biochem J, 2024, 481(6):405-422
S5840	Palifosfamide	Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S1215	Carboplatin	Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Commun, 2024, 15(1):1158 Cell Rep Med, 2024, S2666-3791(24)00201-5
S8056	Lomeguatrib	Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.	Sci Rep, 2024, 14(1):12363 Neurooncol Adv, 2024, 6(1):vdad165 Int J Mol Sci, 2023, 24(20)15179
S3658	O6-Benzylguanine	O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.	Nat Commun, 2023, 14(1):5913 Nat Commun, 2023, 14(1):5913 Neuro Oncol, 2021, 23(6):920-931
S1302	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.	Cancer Res, 2023, 83(16):2750-2762 Comput Struct Biotechnol J, 2023, 21:3827-3840 Comput Struct Biotechnol J, 2023, 21:3827-3840
S4447	Pipobroman	Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6958	Treosulfan	Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.