Tankyrase-1 inhibitor | Tankyrase-1 inhibition

製品コード	製品名	製品説明	Selective / Pan	IC50 / Ki
S6739	MN 64	MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively.	Pan	TNKS1, IC50: 6 nM
S1180	XAV-939	XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.	Pan	TNKS1, IC50: 11 nM
S8876	RK-287107	RK-287107 is a novel, potent and selective tankyrase inhibitor with antitumor activity. RK-287107 inhibits tankyrase-1 and tankyrase-2 in vitro with IC50 of 14.3 nM and 10.6 nM.	Pan	Tankyrase-1, IC50: 14.3 nM
S7239	G007-LK	G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively.	Pan	TNKS1, IC50: 46 nM

Tankyrase-1 阻害剤