ホームページ GPCR & G Protein -Immunology & Inflammation Prostaglandin Receptor PGI2 選択性 作動薬 | 拮抗剤 | モジュレータ
  • PGD1
  • PGD2
  • PGE2
  • PGE4
  • PGF2α
  • PGI2
  • TXA2
  • TXB2

PGI2 選択性 作動薬 | 拮抗剤 | モジュレータ

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S3346 1-Methylnicotinamide chloride

1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation.

 Selective
S0305 RO1138452 RO1138452 (CAY10441) is a potent and selective antagonist of IP (prostacyclin, PGI2) receptor with pKi of 9.3 and 8.7 in human platelets and a recombinant IP receptor system, respectively. Selective PGI2, pKi: 9.3; PGI2, pKi: 8.7
S0325 Treprostinil sodium Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively. Pan IP, Ki: 32 nM