ホームページ Cell Cycle -Protein Tyrosine Kinase DYRK DYRK1 選択性 阻害剤
  • DYRK1
  • DYRK2
  • DYRK3

DYRK1 選択性 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S7338 AZ191 AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively. Selective DYRK1A, IC50: 88 nM; DYRK1B, IC50: 17 nM
S3817 Harmine hydrochloride Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM. Selective DYRK1A, IC50: 33 nM; DYRK1B, IC50: 166 nM