ALK1
ALK2
ALK3
ALK4
TGFβRI/ALK5
ALK6
TGFβRII
TGF-β
Smad3
Smad4
Smad5
ALK7

ALK7 阻害剤

製品コード	製品名	製品説明	Selective / Pan	IC50 / Ki
S7692	A-83-01	A-83-01 is a potent inhibitor of TGF-β type I receptor (ALK5-TD) with IC50 of 12 nM. A-83-01 also inhibits the transcription induced by activin/nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD) with IC50 of 45 nM and 7.5 nM, respectively.Solutions are unstable and should be fresh-prepared.	Pan	ALK7, IC50: 7.5 nM
S1067	SB431542	SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.	Pan