SPHK

SPHK製品

All (7)
SPHK阻害剤 (5)
SPHK活性剤(2)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S7177	PF-543 hydrochloride	PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and K_i of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.	J Transl Med, 2024, 22(1):43 Int J Mol Sci, 2023, 24(9)8303 Cell Res, 2022, 10.1038/s41422-022-00614-0
S7174	Opaganib (ABC294640)	Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.	Cell Res, 2022, 10.1038/s41422-022-00614-0 Bioact Mater, 2022, 15:29-43 Clin Transl Med, 2022, 12(2):e695
S7176	SKI II	SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.	Clin Transl Med, 2022, 12(2):e695 Int J Biol Sci, 2022, 18(7):2994-3005 Int J Biol Sci, 2022, 18(7):2994-3005
S0817	SKI-V	SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.	Cell Death Discov, 2022, 8(1):48 Cell Death Discov, 2022, 8(1):48
S6512	Defensamide (MHP)	Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.
E1218	K6PC-5	K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.	Cell Prolif, 2024, e13604. Int J Biol Sci, 2022, 18(7):2994-3005
S5989	SKI-178	SKI-178 is a potent inhibitors of sphingosine kinase-1 (SphK1) and SphK2 with IC50 values ranging from ∼500 nM to ∼1 μM depending on AML cell lines.
S7177	PF-543 hydrochloride	PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and K_i of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.	J Transl Med, 2024, 22(1):43 Int J Mol Sci, 2023, 24(9)8303 Cell Res, 2022, 10.1038/s41422-022-00614-0
S7174	Opaganib (ABC294640)	Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.	Cell Res, 2022, 10.1038/s41422-022-00614-0 Bioact Mater, 2022, 15:29-43 Clin Transl Med, 2022, 12(2):e695
S7176	SKI II	SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.	Clin Transl Med, 2022, 12(2):e695 Int J Biol Sci, 2022, 18(7):2994-3005 Int J Biol Sci, 2022, 18(7):2994-3005
S0817	SKI-V	SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.	Cell Death Discov, 2022, 8(1):48 Cell Death Discov, 2022, 8(1):48
S5989	SKI-178	SKI-178 is a potent inhibitors of sphingosine kinase-1 (SphK1) and SphK2 with IC50 values ranging from ∼500 nM to ∼1 μM depending on AML cell lines.
S6512	Defensamide (MHP)	Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.
E1218	K6PC-5	K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.	Cell Prolif, 2024, e13604. Int J Biol Sci, 2022, 18(7):2994-3005

SPHK阻害剤の選択性比較