β-Amyloid (1-42), human

製品コード：P1003

β-Amyloid (1-42), human is a peptide fragment composed of 42 amino acids, derived from amyloid precursor protein (APP), and plays a crucial role in Alzheimer's disease (AD). It self-aggregates into oligomers and fibrils, with the oligomeric form being the most neurotoxic. These aggregates form amyloid plaques, a characteristic feature of AD, which interfere with cellular functions, cause mitochondrial dysfunction, and lead to neuronal cell death through oxidative stress, calcium dysregulation, and inflammation.

Amino-acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

CAS No. 107761-42-2

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製品安全説明書

化学情報

保管	3 years-20°C powder 1 years-80°C in solvent	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			１ケ月-20°Cin solvent

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

生物活性

製品説明	β-Amyloid (1-42), human is a peptide fragment composed of 42 amino acids, derived from amyloid precursor protein (APP), and plays a crucial role in Alzheimer's disease (AD). It self-aggregates into oligomers and fibrils, with the oligomeric form being the most neurotoxic. These aggregates form amyloid plaques, a characteristic feature of AD, which interfere with cellular functions, cause mitochondrial dysfunction, and lead to neuronal cell death through oxidative stress, calcium dysregulation, and inflammation.

製品説明

参考
[1] Butterfield DA, et al. Antioxid Redox Signal. 2013 Sep 10;19(8):823-35.

参考

[1] Butterfield DA, et al. Antioxid Redox Signal. 2013 Sep 10;19(8):823-35.

製品情報

Molecular Formula	C₂₀₃H₃₁₁N₅₅O₆₀S
Molecular Weight	4514.04
CAS No.	107761-42-2
Appearance	White powder
Peptide Content (by %N)	≥80%
Purity (by HPLC)	95%min.
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder 1 years-80°C in solvent
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)