p21

p21製品

• All (7)
• p21阻害剤 (3)
• p21活性剤(1)
• p21作動薬(1)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1095	Dacinostat (LAQ824)	Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.	Int J Mol Sci, 2023, 24(17)13660 Clin Transl Med, 2022, 12(5):e798 Cancers (Basel), 2022, 14(19)4708
S6963	APTO-253	APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).	Cell Commun Signal, 2023, 21(1):94
E0455New	Nimbolide	Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. Nimbolide induces apoptosis through inactivation of NF-κB.
S6885	Ailanthone	Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.	Theranostics, 2024, 14(4):1371-1389
S2961	GC7 Sulfate	GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	Exp Mol Med, 2024, 10.1038/s12276-024-01214-1
E1190	UC2288	UC2288 is a novel, cell-permeable, and orally active p21 attenuator, decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability.	Breast Cancer Res, 2024, 26(1):54
S6885	Ailanthone	Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.	Theranostics, 2024, 14(4):1371-1389
E0455New	Nimbolide	Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. Nimbolide induces apoptosis through inactivation of NF-κB.
S2961	GC7 Sulfate	GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	Exp Mol Med, 2024, 10.1038/s12276-024-01214-1
E1190	UC2288	UC2288 is a novel, cell-permeable, and orally active p21 attenuator, decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability.	Breast Cancer Res, 2024, 26(1):54
S1095	Dacinostat (LAQ824)	Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.	Int J Mol Sci, 2023, 24(17)13660 Clin Transl Med, 2022, 12(5):e798 Cancers (Basel), 2022, 14(19)4708
S6885	Ailanthone	Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.	Theranostics, 2024, 14(4):1371-1389
E0455New	Nimbolide	Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. Nimbolide induces apoptosis through inactivation of NF-κB.