MAT2A antagonist | MAT2A inhibitor |MAT2A agonist |MAT2A activator

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S0435	PF-9366	PF-9366 is a human methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.	Nat Commun, 2024, 15(1):8971 J Oral Microbiol, 2024, 16(1):2292375 Neoplasia, 2023, 41:100902
E1485	IDE397 (GSK-4362676)	IDE397 (GSK-4362676) is a potent inhibitor of MAT2A(methionine adenosyltransferase 2A) and exhibits anti-tumor activity in MTAP-deleted PDX models.
E1806^New	AGI-24512	AGI-24512 is an inhibitor of MAT2A with an IC50 of 8 nM. It increases R-Loop formation and DNA damage in MTAP-deleted and WT cell models. It also exhibits anti-proliferative activity in vitro.
S9872	AG-270	AG-270 is a potent and non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor which lessens the intracellular SAM levels and MTAP-null–selective antiproliferative activity.
S0435	PF-9366	PF-9366 is a human methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.	Nat Commun, 2024, 15(1):8971 J Oral Microbiol, 2024, 16(1):2292375 Neoplasia, 2023, 41:100902
E1485	IDE397 (GSK-4362676)	IDE397 (GSK-4362676) is a potent inhibitor of MAT2A(methionine adenosyltransferase 2A) and exhibits anti-tumor activity in MTAP-deleted PDX models.
E1806^New	AGI-24512	AGI-24512 is an inhibitor of MAT2A with an IC50 of 8 nM. It increases R-Loop formation and DNA damage in MTAP-deleted and WT cell models. It also exhibits anti-proliferative activity in vitro.
S9872	AG-270	AG-270 is a potent and non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor which lessens the intracellular SAM levels and MTAP-null–selective antiproliferative activity.
E1806^New	AGI-24512	AGI-24512 is an inhibitor of MAT2A with an IC50 of 8 nM. It increases R-Loop formation and DNA damage in MTAP-deleted and WT cell models. It also exhibits anti-proliferative activity in vitro.

MAT2A

MAT2A製品

MAT2A阻害剤の選択性比較