MAP4K

亜型選択性的な製品

MAP4K2 MAP4K4 MAP4K6 MAP4K7

MAP4K製品

All (8)
MAP4K阻害剤 (8)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S6499	PF-6260933	PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.	bioRxiv, 2023, 2023.04.24.538014 Biomed Pharmacother, 2022, 149:112810 J Cell Sci, 2020, 14;133(9) pii: jcs240077
S8868	NG25	NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.	Int J Biol Sci, 2024, 20(2):606-620 Biochem J, 2022, 479(20):2195-2216 Lab Invest, 2021, 10.1038/s41374-021-00671-w
S0268	DMX-5084	DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.	Commun Biol, 2022, 5-1:1071
E1297	BGB 15025	BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers.
E1944^New	INS018-055(ISM001-055)	INS018-055 (ISM001-055, TNIK&MAP4K4-IN-2, compound 112) is an inhibitor of TNIK and MAP4K4. It exhibits an IC50 values of 12-120 nM on TNIK.
E1161	CompK	CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells.
E2376	KY-05009	KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM, which inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells.
E0946	MAP4K4-IN-3	MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.
S6499	PF-6260933	PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.	bioRxiv, 2023, 2023.04.24.538014 Biomed Pharmacother, 2022, 149:112810 J Cell Sci, 2020, 14;133(9) pii: jcs240077
S8868	NG25	NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.	Int J Biol Sci, 2024, 20(2):606-620 Biochem J, 2022, 479(20):2195-2216 Lab Invest, 2021, 10.1038/s41374-021-00671-w
S0268	DMX-5084	DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.	Commun Biol, 2022, 5-1:1071
E1297	BGB 15025	BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers.
E1944^New	INS018-055(ISM001-055)	INS018-055 (ISM001-055, TNIK&MAP4K4-IN-2, compound 112) is an inhibitor of TNIK and MAP4K4. It exhibits an IC50 values of 12-120 nM on TNIK.
E1161	CompK	CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells.
E2376	KY-05009	KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM, which inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells.
E0946	MAP4K4-IN-3	MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.
E1944^New	INS018-055(ISM001-055)	INS018-055 (ISM001-055, TNIK&MAP4K4-IN-2, compound 112) is an inhibitor of TNIK and MAP4K4. It exhibits an IC50 values of 12-120 nM on TNIK.

MAP4K阻害剤の選択性比較

Tags: MAP4K inhibitor|MAP4K agonist|MAP4K activator|MAP4K inducer|MAP4K antagonist|MAP4K signaling pathway|MAP4K assay kit