cGAS antagonist | cGAS inhibitor | cGAS agonist

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S6841	RU.521	RU.521 (RU320521) is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.	Redox Biol, 2024, 76:103318 J Adv Res, 2024, S2090-1232(24)00499-5 Cancer Lett, 2024, 586:216695
S8944	G150	G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM.	Ecotoxicol Environ Saf, 2024, 277:116357 Virus Res, 2024, 343:199344 PLoS One, 2024, 19(8):e0305962
S9615	PF-06928215	PF-06928215 is a high affinity inhibitor of cyclic GMP-AMP synthase (cGAS) with an IC50 of 4.9 μM.
S0775	IRAK4-IN-4	IRAK4-IN-4 (compound 15) is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) and cyclic GMP-AMP synthase (cGAS) with IC50 of 2.8 nM and 2.1 nM, respectively.
S9945	G140	G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.
S6841	RU.521	RU.521 (RU320521) is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.	Redox Biol, 2024, 76:103318 J Adv Res, 2024, S2090-1232(24)00499-5 Cancer Lett, 2024, 586:216695
S8944	G150	G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM.	Ecotoxicol Environ Saf, 2024, 277:116357 Virus Res, 2024, 343:199344 PLoS One, 2024, 19(8):e0305962
S9615	PF-06928215	PF-06928215 is a high affinity inhibitor of cyclic GMP-AMP synthase (cGAS) with an IC50 of 4.9 μM.
S0775	IRAK4-IN-4	IRAK4-IN-4 (compound 15) is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) and cyclic GMP-AMP synthase (cGAS) with IC50 of 2.8 nM and 2.1 nM, respectively.
S9945	G140	G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.

cGAS

cGAS製品

cGAS阻害剤の選択性比較