PTEN

PTEN製品

All (5)
PTEN阻害剤 (3)
PTEN活性剤(2)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S7310	SF1670	SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.	Nat Biomed Eng, 2024, 10.1038/s41551-024-01273-9 J Biol Chem, 2024, S0021-9258(24)01808-8 Fish Shellfish Immunol, 2024, 146:109384
S8651	bpV (HOpic)	bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.	Cell Rep, 2024, 43(4):114005 Res Sq, 2024, rs.3.rs-4603170 Protein Cell, 2023, 14(5):350-368
S8174	VO-Ohpic trihydrate	VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.	Nature, 2024, 631(8019):170-178 Aging (Albany NY), 2023, 15(6):2275-2292 Stem Cell Res Ther, 2020, 11(1):140
S9190	Oroxin B	Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment.	Environ Pollut, 2023, 323:121306 Theranostics, 2022, 12(2):910-928 J Cancer, 2021, 12(7):2140-2150
S0918	Ginkgolic acid C17:1	Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells.
S7310	SF1670	SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.	Nat Biomed Eng, 2024, 10.1038/s41551-024-01273-9 J Biol Chem, 2024, S0021-9258(24)01808-8 Fish Shellfish Immunol, 2024, 146:109384
S8651	bpV (HOpic)	bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.	Cell Rep, 2024, 43(4):114005 Res Sq, 2024, rs.3.rs-4603170 Protein Cell, 2023, 14(5):350-368
S8174	VO-Ohpic trihydrate	VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.	Nature, 2024, 631(8019):170-178 Aging (Albany NY), 2023, 15(6):2275-2292 Stem Cell Res Ther, 2020, 11(1):140
S9190	Oroxin B	Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment.	Environ Pollut, 2023, 323:121306 Theranostics, 2022, 12(2):910-928 J Cancer, 2021, 12(7):2140-2150
S0918	Ginkgolic acid C17:1	Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells.

PTEN阻害剤の選択性比較