Lipase

Lipase製品

All (15)
Lipase阻害剤 (13)
Lipase活性剤(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S2365	Tanshinone IIA	Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.	Phytomedicine, 2024, 128:155431 J Cancer, 2023, 14(13):2481-2490 J Cancer, 2023, 14(13):2481-2490
S1629	Orlistat	Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.	iScience, 2023, 26(3):106193 iScience, 2023, 26(3):106193 OPARU, 2023, 10.18725/OPARU-48911
S4904	JZL184	JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Biomed Pharmacother, 2022, 149:112798 J Cardiovasc Transl Res, 2022, 10.1007/s12265-022-10323-z
S7364	Atglistatin	Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.	Bone Joint Res, 2024, 13(4):137-148 Exp Eye Res, 2024, 238:109743 Sci Adv, 2024, 10(33):eado1533
S9404	Pristimerin	Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon.	Cell Death Dis, 2020, 14;11(4):232
S7457	XEN445	XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
S7543	JW642	JW642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
S9234	Schaftoside	Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
S0536	Ibrolipim	Ibrolipim (NO-1886) is an effective lipoprotein lipase (LPL) activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.
S6609	JZL195	JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.
S4825	Pancreatin	Pancreatin (Pancrelipase, Pancreatic enzymes), are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to pancreatic problems.(PROTEASE ACTIVITY ≥ 275 USP.u/mg；Amvlase activity ≥ 275 USP.u/mg；Lipase Activity ≥ 22 USP.u/mg)
S6550	URB602	URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).
S8823	ABX-1431	ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
S4930	Cetilistat	Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo
E1752^New	JNJ-42226314	JNJ-42226314 is a potent, selective, and reversible noncovalent inhibitor of monoacylglycerol lipase (MAGL). It enhances the expression of endocannabinoid 2-arachidonoylglycerol (2-AG) and exhibits antinociceptive efficacy in models of neuropathic and inflammatory pain.
S2365	Tanshinone IIA	Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.	Phytomedicine, 2024, 128:155431 J Cancer, 2023, 14(13):2481-2490 J Cancer, 2023, 14(13):2481-2490
S1629	Orlistat	Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.	iScience, 2023, 26(3):106193 iScience, 2023, 26(3):106193 OPARU, 2023, 10.18725/OPARU-48911
S4904	JZL184	JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Biomed Pharmacother, 2022, 149:112798 J Cardiovasc Transl Res, 2022, 10.1007/s12265-022-10323-z
S7364	Atglistatin	Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.	Bone Joint Res, 2024, 13(4):137-148 Exp Eye Res, 2024, 238:109743 Sci Adv, 2024, 10(33):eado1533
S9404	Pristimerin	Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon.	Cell Death Dis, 2020, 14;11(4):232
S7457	XEN445	XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
S7543	JW642	JW642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
S9234	Schaftoside	Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
S6609	JZL195	JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.
S6550	URB602	URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).
S8823	ABX-1431	ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
S4930	Cetilistat	Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo
E1752^New	JNJ-42226314	JNJ-42226314 is a potent, selective, and reversible noncovalent inhibitor of monoacylglycerol lipase (MAGL). It enhances the expression of endocannabinoid 2-arachidonoylglycerol (2-AG) and exhibits antinociceptive efficacy in models of neuropathic and inflammatory pain.
S0536	Ibrolipim	Ibrolipim (NO-1886) is an effective lipoprotein lipase (LPL) activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.
E1752^New	JNJ-42226314	JNJ-42226314 is a potent, selective, and reversible noncovalent inhibitor of monoacylglycerol lipase (MAGL). It enhances the expression of endocannabinoid 2-arachidonoylglycerol (2-AG) and exhibits antinociceptive efficacy in models of neuropathic and inflammatory pain.

Lipase阻害剤の選択性比較