FAAH

FAAH製品

All (11)
FAAH阻害剤 (11)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S2631	URB597	URB597 (KDS-4103) is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.	Mol Metab, 2022, 65:101597 Int J Nanomedicine, 2021, 16:3661-3678 Int J Mol Sci, 2021, 22(14)7711
S2377	Biochanin A	Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.	Mol Neurobiol, 2022, 10.1007/s12035-021-02674-6 Front Oncol, 2021, 11:652008 J Med Virol, 2019, 91(8):1440-1447
S2666	PF-3845	PF-3845 is a potent, selective and irreversible FAAH inhibitor with K_i of 230 nM, showing negligible activity against FAAH2.	Elife, 2020, 9;9:e55211 Front Pharmacol, 2020, 11:266 Sci Rep, 2020, 10(1):15556
S0497	JNJ-42165279	JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.	Cell Death Differ, 2022, 10.1038/s41418-022-01054-4
S2421	PF-04457845	PF-04457845 (PF-4457845) is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily.	Front Chem, 2018, 6:441
S5329	FAAH-IN-2	FAAH-IN-2 is an inhibitor of fatty acid amide hydrolase (FAAH).
S6609	JZL195	JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.
S3586	URB937	URB937 is an orally active and peripherally restricted FAAH inhibitor with IC50 of 26.8 nM and increases anandamide levels.
S2828	JNJ-1661010	JNJ-1661010 (Takeda-25) is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2.
S5932	BIA 10-2474	BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.
S8052	LY-2183240	LY-2183240 is a potent, covalent inhibitor of the EC-degrading enzyme fatty acid amide hydrolase (FAAH). LY-2183240 disrupts the cellular uptake of the lipid endocannabinoid (EC) anandamide and promote analgesia in vivo. LY-2183240 is also an inhibitor of monoacylgylcerol lipase (MGL).
S2631	URB597	URB597 (KDS-4103) is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.	Mol Metab, 2022, 65:101597 Int J Nanomedicine, 2021, 16:3661-3678 Int J Mol Sci, 2021, 22(14)7711
S2377	Biochanin A	Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.	Mol Neurobiol, 2022, 10.1007/s12035-021-02674-6 Front Oncol, 2021, 11:652008 J Med Virol, 2019, 91(8):1440-1447
S2666	PF-3845	PF-3845 is a potent, selective and irreversible FAAH inhibitor with K_i of 230 nM, showing negligible activity against FAAH2.	Elife, 2020, 9;9:e55211 Front Pharmacol, 2020, 11:266 Sci Rep, 2020, 10(1):15556
S0497	JNJ-42165279	JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.	Cell Death Differ, 2022, 10.1038/s41418-022-01054-4
S2421	PF-04457845	PF-04457845 (PF-4457845) is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily.	Front Chem, 2018, 6:441
S5329	FAAH-IN-2	FAAH-IN-2 is an inhibitor of fatty acid amide hydrolase (FAAH).
S6609	JZL195	JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.
S3586	URB937	URB937 is an orally active and peripherally restricted FAAH inhibitor with IC50 of 26.8 nM and increases anandamide levels.
S2828	JNJ-1661010	JNJ-1661010 (Takeda-25) is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2.
S5932	BIA 10-2474	BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.
S8052	LY-2183240	LY-2183240 is a potent, covalent inhibitor of the EC-degrading enzyme fatty acid amide hydrolase (FAAH). LY-2183240 disrupts the cellular uptake of the lipid endocannabinoid (EC) anandamide and promote analgesia in vivo. LY-2183240 is also an inhibitor of monoacylgylcerol lipase (MGL).

FAAH阻害剤の選択性比較

FAAHシグナル伝達経路

Tags: FAAH inhibition | FAAH activity | FAAH assay | FAAH inhibitors clinical trials | FAAH inhibitor review