Decarboxylase

Decarboxylase製品

All (13)
Decarboxylase阻害剤 (12)
Decarboxylase活性剤(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S4582	Eflornithine (DFMO) hydrochloride hydrate	Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.	Front Oncol, 2023, 13:1212604 mBio, 2022, 13(5):e0219422 iScience, 2022, 25(3):103881
S2453	Benserazide HCl	Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.	Front Pharmacol, 2024, 15:1404532 Elife, 2022, 11e72668 Front Pharmacol, 2022, 13:903235
S1891	Carbidopa	Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.	Signal Transduct Target Ther, 2021, 6(1):77 J Cell Physiol, 2021, 10.1002/jcp.30587 PLoS One, 2017, 12(3):e0173240
S0108	AZ-33	AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	FASEB J, 2022, 36(3):e22229 Front Mol Biosci, 2021, 8:806650
S3086	Maleic acid	Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels.
E2354	Valepotriate	Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABA_A, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.
S1642	Methyldopa	Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.	J Immunother Cancer, 2024, 12(11)e009805
E0654	D-Arginine	D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis.
S5448	S(-)-Carbidopa	S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
E1189	TES-1025	TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
S5444	4-Bromo-3-hydroxybenzoic acid	4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.
S5579	Chelidonic acid	Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.
S5409	Chelidamic acid hydrate	Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
S4582	Eflornithine (DFMO) hydrochloride hydrate	Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.	Front Oncol, 2023, 13:1212604 mBio, 2022, 13(5):e0219422 iScience, 2022, 25(3):103881
S2453	Benserazide HCl	Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.	Front Pharmacol, 2024, 15:1404532 Elife, 2022, 11e72668 Front Pharmacol, 2022, 13:903235
S1891	Carbidopa	Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.	Signal Transduct Target Ther, 2021, 6(1):77 J Cell Physiol, 2021, 10.1002/jcp.30587 PLoS One, 2017, 12(3):e0173240
S0108	AZ-33	AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	FASEB J, 2022, 36(3):e22229 Front Mol Biosci, 2021, 8:806650
S3086	Maleic acid	Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels.
S1642	Methyldopa	Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.	J Immunother Cancer, 2024, 12(11)e009805
E0654	D-Arginine	D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis.
S5448	S(-)-Carbidopa	S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
E1189	TES-1025	TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
S5444	4-Bromo-3-hydroxybenzoic acid	4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.
S5579	Chelidonic acid	Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.
S5409	Chelidamic acid hydrate	Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
E2354	Valepotriate	Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABA_A, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.

Decarboxylase阻害剤の選択性比較

Tags: Decarboxylase inhibition | Decarboxylase pathway | Decarboxylase activation | Decarboxylase inhibitor review