DDR

亜型選択性的な製品

DDR1 DDR2

DDR製品

All (4)
DDR阻害剤 (4)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7498	DDR1-IN-1	DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.	Biomater Sci, 2022, 10.1039/d2bm00543c EMBO Mol Med, 2021, e11814 Eur J Cell Biol, 2020, 99(7):151122
S7014	Merestinib (LY2801653)	Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.	NPJ Breast Cancer, 2024, 10(1):65 Cancers (Basel), 2024, 16(12)2253 J Clin Invest, 2021, 131(11)146987
E0621	FGFR1/DDR2 inhibitor 1	FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2).
S6817	VU6015929	VU6015929 is a selective Discoidin Domain Receptor 1/2 (DDR1/2) inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively. VU6015929 potently inhibits collagen-IV production.
S7498	DDR1-IN-1	DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.	Biomater Sci, 2022, 10.1039/d2bm00543c EMBO Mol Med, 2021, e11814 Eur J Cell Biol, 2020, 99(7):151122
S7014	Merestinib (LY2801653)	Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.	NPJ Breast Cancer, 2024, 10(1):65 Cancers (Basel), 2024, 16(12)2253 J Clin Invest, 2021, 131(11)146987
E0621	FGFR1/DDR2 inhibitor 1	FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2).
S6817	VU6015929	VU6015929 is a selective Discoidin Domain Receptor 1/2 (DDR1/2) inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively. VU6015929 potently inhibits collagen-IV production.

DDR阻害剤の選択性比較

Tags: DDR inhibitor|DDR agonist|DDR activator|DDR inducer|DDR antagonist|DDR signaling pathway|DDR assay kit