Silmitasertib (CX-4945) sodium salt

製品コードS0707 バッチS070706

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₉H₁₁ClN₃NaO₂

分子量

371.75

CAS No.

1309357-15-0

Solubility (25°C)*

体外

DMSO

24 mg/mL (64.55 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution	5% DMSO 1 95% Corn oil	0.15mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	1.2mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 24 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Cell-free assays
	濃度	1 nM (IC50)
	反応時間
	実験の流れ
動物実験	動物モデル	Female CrTac:Ncr-Foxn1 mice
	投薬量	25 mg/kg
	投与方法	o.g.

参考

[1] Adam Siddiqui-Jain, et al. Cancer Res. 2010 Dec 15;70(24):10288-98.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

CK2 activity is crucial for proper glucagon expression [ Diabetologia, 2024, 10.1007/s00125-024-06128-1]	PubMed: 38503901
Mitochondrial ALDH2 improves ß-cell survival and function against doxorubicin-induced apoptosis by targeting CK2 signaling [ J Diabetes Investig, 2024, 15(6):684-692]	PubMed: 38713732
AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity [ Proc Natl Acad Sci U S A, 2022, 119(12):e2114336119]	PubMed: 35290121
Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation [ Haematologica, 2022, 10.3324/haematol.2022.281668]	PubMed: 36226498
CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway [ Br J Pharmacol, 2022, 10.1111/bph.15945]	PubMed: 36070072
Protein Kinase CK2 acts as a molecular brake to control NADPH oxidase 1 activation and colon inflammation [ Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00003-0]	PubMed: 35031518
Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2 [ Int J Mol Sci, 2022, 23(13)7274]	PubMed: 35806278
Inhibitory Response to CK II Inhibitor Silmitasertib and CDKs Inhibitor Dinaciclib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines [ Int J Mol Sci, 2022, 23(8)4409]	PubMed: 35457227
Targeting AKT and CK2 represents a novel therapeutic strategy for SMO constitutive activation-driven medulloblastoma [ CNS Neurosci Ther, 2022, 10.1111/cns.13835]	PubMed: 35419951
CIGB-300 Peptide Targets the CK2 Phospho-Acceptor Domain on Human Papillomavirus E7 and Disrupts the Retinoblastoma (RB) Complex in Cervical Cancer Cells [ Viruses, 2022, 14(8)1681]	PubMed: 36016303

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。