SGC-CBP30

製品コードS7256 バッチS725601

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₈H₃₃ClN₄O₃
	分子量	509.04	CAS No.	1613695-14-9
Solubility (25°C)*	体外	DMSO	100 mg/mL (196.44 mM)
		Ethanol	100 mg/mL (196.44 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.
in vitro	As a CREBBP/EP300-selective chemical probe, SGC-CBP30 shows moderate cytotoxicity in U2OS cells and HeLa cells. ^[1]
特徴	CREBBP/EP300-selective chemical probe.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	COLO-320-HSR cells
	濃度	20 μM
	反応時間	6 h
	実験の流れ	Cells were then treated for 6 hours with 20μM SGC-SCP30 or DMSO.
動物実験	動物モデル	Sprague-Dawley rats
	投薬量	25 mg/kg
	投与方法	p.o.

参考

カスタマーフィードバック

: Data from [Data independently produced by , , Cell, 2018, 175(1):186-199]

: Data from [Data independently produced by , , J Proteome Res, 2017, 16:1743−1752]

: Data from [Data independently produced by , , Biomed Pharmacother, 2018, 106:1727-1733]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

High-throughput discovery and characterization of viral transcriptional effectors in human cells [ Cell Syst, 2023, 14(6):482-500.e8]	PubMed: 37348463
NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer [ Cell Rep, 2023, 42(8):112963]	PubMed: 37561631
Chemical-induced epigenome resetting for regeneration program activation in human cells [ Cell Rep, 2023, 42(6):112547]	PubMed: 37224020
Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma [ Mol Carcinog, 2023, 62(11):1717-1730]	PubMed: 37493106
Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complex [ J Hepatol, 2022, 76(4):921-933]	PubMed: 34953958
Structural insights into p300 regulation and acetylation-dependent genome organisation [ Nat Commun, 2022, 13(1):7759]	PubMed: 36522330
DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300 [ Nucleic Acids Res, 2022, gkac585]	PubMed: 35801925
Acetylation of Checkpoint suppressor 1 enhances its stability and promotes the progression of triple-negative breast cancer [ Cell Death Discov, 2022, 8(1):474]	PubMed: 36450706
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer [ Clin Epigenetics, 2022, 14(1):147]	PubMed: 36371227
Transcriptional Activation of Ecdysone-Responsive Genes Requires H3K27 Acetylation at Enhancers [ Int J Mol Sci, 2022, 23(18)10791]	PubMed: 36142704

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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