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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C42H72O14 |
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分子量 | 801.01 | CAS No. | 69884-00-0 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (124.84 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist. |
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in vitro | Pseudoginsenoside F11 (PF11) promotes the differentiation of 3T3-L1 preadipocytes. It promotes adipogenesis by activating PPARγ[1]. PF11 significantly suppresses the release of ROS and proinflammatory mediators induced by LPS in a microglial cell line N9 including NO, PGE2, IL-1β, IL-6 and TNF-α. Moreover, PF11 inhibits interaction and expression of TLR4 and MyD88 in LPS-activated N9 cells, resulting in an inhibition of the TAK1/IKK/NF-κB signaling pathway. PF11 also inhibited the phosphorylation of Akt and MAPKs induced by LPS in N9 cells[2]. |
in vivo | In in vivo studies, PF11 mitigated the microglial activation and proinflammatory factors expression obviously in both cortex and hippocampus in mice injected intrahippocampally with LPS. PF11 exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways. It may exert therapeutic effects for neurodegenerative disease associated with neuroinflammation[2]. |
細胞アッセイ | 細胞株 | 3T3-L1 preadipocytes |
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濃度 | 0, 20, 40 μM | |
反応時間 | 8 days | |
実験の流れ | 3T3-L1 preadipocytes are induced to differentiate with 0, 20, 40 μM Pseudoginsenoside F11 (p-F11) or 0.5 μM rosiglitazone in the absence or presence of 20 μM GW9662 for 8 days. |
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動物実験 | 動物モデル | male C57BL/6 mice |
投薬量 | 8 mg/kg | |
投与方法 | oral |
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長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。