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Synonyms | SIRT6-IN-1 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C19H14N2O6 |
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分子量 | 366.32 | CAS No. | 887686-02-4 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 73 mg/mL (199.27 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication. |
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in vitro | OSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression[1]. |
細胞アッセイ | 細胞株 | BxPC3 cells |
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濃度 | 100 μM | |
反応時間 | 0, 2, 6, 18, 24 h | |
実験の流れ | 4 × 105 BxPC3 cells are plated in six-well plates and allowed to adhere for 24 h. Thereafter, cells are stimulated with 100 μM OSS-128167 or the respective amounts of vehicle DMSO for the indicated time amounts. Finally, cells are used for protein lysate generation, and total H3 and acetylated H3K9 levels are detected by immunoblotting. |
Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery [ Antioxidants (Basel), 2023, 12(3)714] | PubMed: 36978961 |
Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury via SIRT6-Mediated Autophagy Activation [ Oxid Med Cell Longev, 2022, 2022:9035547] | PubMed: 36160707 |
SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart [ Cell Biol Toxicol, 2022, 10.1007/s10565-022-09735-z] | PubMed: 35798905 |
Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress [ Biochem Pharmacol, 2022, 199:115022] | PubMed: 35358477 |
Downregulation of Sirt6 by CD38 promotes cell senescence and aging [ Aging (Albany NY), 2022, 14(23):9730-9757] | PubMed: 36490326 |
Downregulation of Sirt6 by CD38 promotes cell senescence and aging [ Aging (Albany NY), 2022, 14(23):9730-9757] | PubMed: 36490326 |
Deacetylation of ATG4B promotes autophagy initiation under starvation [ Sci Adv, 2022, 8(31):eabo0412] | PubMed: 35921421 |
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1 [ NPJ Precis Oncol, 2021, 5(1):20] | PubMed: 33742100 |
SIRT6 Maintains Redox Homeostasis to Promote Porcine Oocyte Maturation [ Front Cell Dev Biol, 2021, 9:625540] | PubMed: 33718364 |
SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Antagonizing DNMT1 [ Front Cell Dev Biol, 2021, 9:648627] | PubMed: 34239868 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。