ML385

製品コードS8790 バッチS879004

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₂₉H₂₅N₃O₄S

分子量

511.59

CAS No.

846557-71-9

Solubility (25°C)*

体外

DMSO (warmed with 50ºC water bath)

100 mg/mL (195.46 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution

10% DMSO 1 40% PEG 300 2 5%Tween80 3 45%ddH2O

3.0mg/ml

Taking the 1 mL working solution as an example, add 100 μL of 30 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 450 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.
in vitro	ML385 shows anti-tumor activity in NSCLC (subcutaneous and orthotopic NSCLC models) both as a single agent and in combination. The PK profile tested in CD-1 mice shows that ML385 has a half-life (t_1/2 = 2.82 h) after IP injection (30 mg/kg)^[1]. ML385 could alleviate the pancreatic injury^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	A549 cells
	濃度	5 μM
	反応時間	24, 48 and 72 h
	実験の流れ	--
動物実験	動物モデル	male CD-1 mice
	投薬量	30 mg/kg
	投与方法	i.p.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

A novel effect of sulforaphane on promoting mouse granulosa cells proliferation via the NRF2-TKT pathway [ J Adv Res, 2024, S2090-1232(24)00422-3]	PubMed: 39341455
Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway [ J Adv Res, 2024, S2090-1232(24)00491-0]	PubMed: 39505146
IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1 [ Int J Biol Sci, 2024, 20(6):2323-2338]	PubMed: 38617533
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC [ Cell Death Dis, 2024, 15(2):175]	PubMed: 38413563
TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway [ Phytomedicine, 2024, 129:155597]	PubMed: 38643713
Curcumol ameliorates neuroinflammation after cerebral ischemia-reperfusion injury via affecting microglial polarization and Treg/Th17 balance through Nrf2/HO-1 and NF-κB signaling [ Cell Death Discov, 2024, 10(1):300]	PubMed: 38914581
Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway [ Cell Death Discov, 2024, 10(1):35]	PubMed: 38238299
Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice [ Biol Res, 2024, 57(1):43]	PubMed: 38915069
Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation [ Nutrients, 2024, 16(14)2263]	PubMed: 39064706
Hydrophobic Components in Light-Yellow Pulp Sweet Potato (Ipomoea batatas (L.) Lam.) Tubers Suppress LPS-Induced Inflammatory Responses in RAW264.7 Cells via Activation of the Nrf2 Pathway [ Nutrients, 2024, 16(4)563]	PubMed: 38398887

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。