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Synonyms | CL 59806 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C23H27N3O7.HCl |
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分子量 | 493.94 | CAS No. | 13614-98-7 | |
Solubility (25°C)* | 体外 | Water | 14 mg/mL warmed with 50ºC water bath (28.34 mM) | |
DMSO | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Minocycline HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis. |
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in vitro | Minocycline is a second-generation tetracycline used in humans, which effectively crosses the blood−brain barrier. It inhibits the activity of caspase-1, caspase-3, inducible form of nitric oxide synthetase (iNOS) and p38 mitogen-activated protein kinase (MAPK). After experimental ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase (iNOS) upregulation, and decreases infarct size. Minocycline inhibits mitochondrial permeability-transition-mediated cytochrome c release. Minocycline-mediated inhibition of cytochrome c release is demonstrated in vivo, in cells, and in isolated mitochondria. [2] |
in vivo | Minocycline is a semi-synthetic tetracycline derivative which is well absorbed and distributed in body tissues and is suitable for twice daily administration. Minocycline's effects are related to the inhibition of protein synthesis. Although minocycline's broader spectrum of activity, compared to other members of the group, includes activity against Neisseria meningitidis, its use as a prophylaxis is no longer recomended because of side effects (dizziness and vertigo). [1] Minocycline is remarkable neuroprotective qualities in models of cerebral ischaemia, traumatic brain injury, and Huntington's and Parkinson's disease. The neuroprotective action of minocycline may include its inhibitory effect on 5-lipoxygenase, an inflammatory enzyme associated with brain aging. [3] |
細胞アッセイ | 細胞株 | OVCAR-3, SKOV-3 and A2780 cells |
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濃度 | IC50 values of 62.0, 56.1 and 59.5 μM, respectively | |
反応時間 | 72 h | |
実験の流れ | Cells were treated with various concentrations of drug for 72 h. |
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動物実験 | 動物モデル | Female nude mice |
投薬量 | 10 or 30 mg/kg | |
投与方法 |
Calcitonin gene-related peptide attenuated discogenic low back pain in rats possibly via inhibiting microglia activation [ Heliyon, 2024, 10(3):e25906] | PubMed: 38371980 |
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm [ Protein Cell, 2023, 14(4):262-278] | PubMed: 37084236 |
Comparative assessment of embryotoxicity of 2,4,6-triiodophenol to mouse blastoid and pre-implantation embryo models [ Ecotoxicol Environ Saf, 2023, 252:114608] | PubMed: 36738612 |
Adolescent microglia stimulation produces long-lasting protection against chronic stress-induced behavioral abnormalities in adult male mice [ Brain Behav Immun, 2022, 105:44-66] | PubMed: 35781008 |
Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice [ J Neuroinflammation, 2022, 19(1):12] | PubMed: 34996472 |
Intratarget Microdosing for Deep Phenotyping of Multiple Drug Effects in the Live Brain [ Front Bioeng Biotechnol, 2022, 10:855755] | PubMed: 35372313 |
Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson's Disease Mouse Model [ Int J Mol Sci, 2022, 23(5)2793] | PubMed: 35269933 |
Granulocyte-macrophage colony-stimulating factor-triggered innate immune tolerance against chronic stress-induced behavioral abnormalities in mice [ Int Immunopharmacol, 2022, 109:108924] | PubMed: 35704970 |
Protein Expression Landscape Defines the Formation Potential of Mouse Blastoids From EPSCs [ Front Cell Dev Biol, 2022, 10:840492] | PubMed: 35211474 |
Protective Effect of Minocycline Hydrochloride on the Mouse Embryonic Development Against Suboptimal Environment [ Front Cell Dev Biol, 2022, 10:799042] | PubMed: 35178387 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。