MCC950 Sodium

製品コードS7809 バッチS780904

化学情報

	Synonyms	CP-456773 Sodium, CRID3 Sodium	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₀H₂₃N₂O₅S.Na
	分子量	426.46	CAS No.	256373-96-3
Solubility (25°C)*	体外	Water	85 mg/mL (199.31 mM)
		Ethanol	85 mg/mL (199.31 mM)
		DMSO	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
in vitro	MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.^[1]
in vivo	MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome. ^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	H9c2 cardiomyocyte cells
	濃度	7 nM
	反応時間	24 h
	実験の流れ	Cardiomyocytes were treated with NLRP3 inhibitor MCC950 for 24 h.
動物実験	動物モデル	C57BL/6 mice
	投薬量	50 mg/kg
	投与方法	i.p.

参考

カスタマーフィードバック

: Data from [Data independently produced by , , ARTHRITIS & RHEUMATOLOGY, 2017, 69(8):1636-1646]

: Data from [Data independently produced by , , Biochem Pharmacol, 2018, 154:278-292]

: Data from [Data independently produced by , , Biochem Biophys Res Commun, 2018, 503(4):3031-3037]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism [ Circ Res, 2024, 135(9):933-950]	PubMed: 39234670
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome [ Bone Res, 2024, 12(1):53]	PubMed: 39242551
P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis [ Int J Biol Sci, 2024, 20(9):3393-3411]	PubMed: 38993566
YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3 [ Cell Death Dis, 2024, 15(5):360]	PubMed: 38789414
Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T cells [ Cell Rep, 2024, 43(3):113954]	PubMed: 38492221
A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages [ Cell Rep, 2024, 43(4):113981]	PubMed: 38520688
RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis [ PLoS Pathog, 2024, 20(8):e1012387]	PubMed: 39213434
UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis [ Int Immunopharmacol, 2024, 141:112935]	PubMed: 39159561
C4b-Binding Protein and Factor H Inhibit Inflammasome Activation during Group A Streptococci Infection in Human Cells [ J Innate Immun, 2024, 1-25.]	PubMed: 39496236
sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway [ Biology (Basel), 2024, 13(2)87]	PubMed: 38392305

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。