Fer-1 (Ferrostatin-1)

製品コードS7243 バッチS724304

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₅H₂₂N₂O₂
	分子量	262.35	CAS No.	347174-05-4
Solubility (25°C)*	体外	DMSO	52 mg/mL (198.2 mM)
		Ethanol	52 mg/mL (198.2 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Fer-1 (Ferrostatin-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
in vitro	Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 does not inhibit extracellular signal -regulated kinase (ERK) phos-phorylation or arrest the proliferation of HT-1080 cells, suggesting that it does not inhibit the MEK/ERK pathway, chelate iron, or inhibit protein synthesis. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 readily oxidizes the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) under cell-free conditions. ^[1]
in vivo	Ferrostatin-1 (Fer-1), a synthetic antioxidant, is a potent and selective inhibitor of ferroptosis. It acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HT-1080 cells
	濃度	60 nM (EC50)
	反応時間	24 h
	実験の流れ	Erastin treated cells were incubated with ferrostatin-1 at 37˚C for 24 hr and viability was assessed using Alamar Blue assay.
動物実験	動物モデル	C57BL/6 mice
	投薬量	10 mg/kg
	投与方法	i.n.

参考

カスタマーフィードバック

: Data from [Data independently produced by , , Hepatology, 2016, 64(2):488-500]

: Data from [Data independently produced by , , Cancer Res, 2017, 77(8):2064-2077]

: Data from [Data independently produced by , , Oncogene, 2015, 10.1038/onc.2015.32]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism [ Nat Commun, 2025, 16(1):509]	PubMed: 39779666
Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis [ Cell Rep Med, 2025, 6(2):101928]	PubMed: 39879992
A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma [ Biomaterials, 2025, 319:123168]	PubMed: 40015005
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation [ EMBO J, 2025, 10.1038/s44318-025-00369-5]	PubMed: 39881208
ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 [ Biomark Res, 2025, 13(1):17]	PubMed: 39849645
CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway [ J Adv Res, 2025, S2090-1232(25)00058-X]	PubMed: 39870301
LncRNA CRCMSL interferes in phospholipid unsaturation to suppress colorectal cancer progression via reducing membrane fluidity [ J Adv Res, 2025, S2090-1232(25)00075-X]	PubMed: 39921055
Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells [ Cell Death Dis, 2025, 16(1):28]	PubMed: 39827156
Pifithrin-μ sensitizes mTOR-activated liver cancer to sorafenib treatment [ Cell Death Dis, 2025, 16(1):42]	PubMed: 39863613
Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism [ Br J Cancer, 2025, 132(4):384-400]	PubMed: 39706989

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。