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Synonyms | L-743872 | Storage (From the date of receipt) |
3 years -20°C(in the dark) powder | |
化学式 | C52H88N10O15.2C2H4O2 |
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分子量 | 1213.42 | CAS No. | 179463-17-3 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (82.41 mM) | |
Water | 100 mg/mL (82.41 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor. |
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in vitro | Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Prior studies have shown in vitro activity of caspofungin acetate using the reference methods, broth microdilution or macrodilution, for antifungal susceptibility testing of Candida species established by the National Committee for Clinical Laboratory Standards 1997 guidelines against a variety of Candida species including Candida krusei. Although caspofungin acetate is only Food and Drug Administration-approved for the treatment of aspergillosis, there is information showing that many Candida species are susceptible. The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate are as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0) |
細胞アッセイ | 細胞株 | Vero cells |
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濃度 | 20.78 μM | |
反応時間 | 2-3 days | |
実験の流れ | Vero cells were treated with the indicated concentrations of drugs for 2- or 3-days incubation |
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動物実験 | 動物モデル | Complement component 5-deficient DBA/2N mice |
投薬量 | 1, 2, 4, or 8 mg/kg/day | |
投与方法 | i.p. |
Antiviral Activity of Micafungin and Its Derivatives against SARS-CoV-2 RNA Replication [ Viruses, 2023, 15(2)452] | PubMed: 36851666 |
Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases [ BMC Med, 2022, 20(1):359] | PubMed: 36266654 |
Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant Klebsiella pneumoniae [ Comput Struct Biotechnol J, 2022, 20:1077-1087] | PubMed: 35284046 |
Synergistic in-vitro antiviral effects of combination treatment using anidulafungin and T-1105 against Zika virus infection [ Antiviral Res, 2021, S0166-3542(21)00178-9] | PubMed: 34648875 |
Micafungin Inhibits Dengue Virus Infection through the Disruption of Virus Binding, Entry, and Stability [ Pharmaceuticals (Basel), 2021, 14(4)338] | PubMed: 33917182 |
Caspofungin Suppresses Brain Cell Necroptosis in Ischemic Stroke Rats via Up-Regulation of Pellino3 [ Cardiovasc Drugs Ther, 2021, 10.1007/s10557-021-07231-w] | PubMed: 34495409 |
Inhibiting Fungal Echinocandin Resistance by Small-Molecule Disruption of Geranylgeranyltransferase Type I Activity. [ Antimicrob Agents Chemother, 2020, 64(2)] | PubMed: 31791942 |
The fungal cell wall as a target for the development of new antifungal therapies. [ Biotechnol Adv, 2019, 37(6):107352] | PubMed: 30797093 |
Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus. [ J Antimicrob Chemother, 2019, 74(10):2950-2958] | PubMed: 31361006 |
Antifungal Activity in Compounds from the Australian Desert Plant Eremophila alternifolia with Potency Against Cryptococcus spp. [ Antibiotics (Basel), 2019, 8(2)] | PubMed: 30935155 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。