Bornyl acetate

化学情報

溶剤液（一定の濃度）を調合する

生物活性

プロトコル(参考用のみ)

参考

製品コードS3893 バッチS389302

印刷

Synonyms

Isobornyl acetate, Bornyl acetic ether, 2-Camphanol acetate

Storage
(From the date of receipt)

2 years -80°C liquid

化学式

C₁₂H₂₀O₂

分子量

196.29

CAS No.

76-49-3

Solubility (25°C)*

体外

DMSO

39 mg/mL (198.68 mM)

Ethanol

39 mg/mL (198.68 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution	5% DMSO 1 95% Corn oil	1.95mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 39 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	1.95mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 39 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

細胞アッセイ	細胞株	RAW 264.7 cells.
	濃度	0-500 μg/mL
	反応時間	18 h
	実験の流れ	RAW 264.7 cells are cultured with bornyl acetate (0-500 μg/mL) in the absence or presence of LPS (1 mg/L) for 18 h. Cell viability is assessed by MTT reduction assays.
動物実験	動物モデル	BALB/c mice
	投薬量	25, 50, and 100mg/kg
	投与方法	i.p.

Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.

in vitro

Bornyl acetate induces dose-dependent growth inhibitory effects on human gastric cancer cells in vitro. Bornyl acetate potentiates the anticancer activity of 5-FU in human gastric cancer (SGC-7901) cells by inducing apoptosis, DNA fragmentation as well as G2/M cell cycle arrest^[2].

Bornyl acetate downregulates the levels of proinflammatory cytokines in vitro and in vivo; reduces the number of total cells, neutrophils, and macrophages in BALF; attenuates the histologic alterations in the lung; decreases the wet-to-dry weight ratio in BALF; and suppresses NF-kappa-B inhibitor alpha, extracellular regulated protein kinases, c-JunN-terminal kinase, p38 mitogen-activated protein kinase activation^[1].

0.985 g/mL at 25 °C

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。