受注:045-509-1970 |
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Synonyms | β-NM, NMN | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C11H15N2O8P |
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分子量 | 334.22 | CAS No. | 1094-61-7 | |
Solubility (25°C)* | 体外 | Water | 67 mg/mL (200.46 mM) | |
DMSO | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase. |
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in vitro | Nicotinamide mononucleotide, the NAD+ precursor, rescues the NAD+/NADH ratio and exerts anti-senescent effects by activating SIRT1.[1] |
in vivo | NMN reduces the loss of cochlear hair cells caused by cisplatin and improves hearing in C57BL/6 mice, by supplementation of NAD+ through de novo and salvage synthesis pathways.[2] |
細胞アッセイ | 細胞株 | mouse AT2 cells strain MLE-12 |
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濃度 | 500 μM | |
反応時間 | -- | |
実験の流れ | The mouse AT2 cells strain MLE-12 are cultured in DMEM with 10% FBS at 37 ℃ in a humidified atmosphere containing 5% CO2. Cells are treated with rapamycin (10 nM), bafilomycin (5 nM), 3 MA (3 mM), SRT1720 (4 μM), Ex527 (10 μM), NMN (500 μM), Olaparib (40 μM) and mitoquinone (50 nM). β-galactosidase staining is performed based on the manufacture s instructions. Relative protein expression levels are measured by Western blot. The level of NAD+/NADH is quantified by an NAD+/NADH detection kit. |
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動物実験 | 動物モデル | C57BL/6 mice |
投薬量 | 100 mg/kg | |
投与方法 | i.g., i.p. |
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SIRT1 stabilizes β-TrCP1 to inhibit Snail1 expression in maintaining intestinal epithelial integrity to alleviate colitis [ Cell Mol Gastroenterol Hepatol, 2024, S2352-345X(24)00108-5] | PubMed: 38729522 |
NAD+ regulates nucleotide metabolism and genomic DNA replication [ Nat Cell Biol, 2023, 10.1038/s41556-023-01280-z] | PubMed: 37957325 |
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism [ Mol Psychiatry, 2023, 10.1038/s41380-023-02372-w] | PubMed: 38135757 |
Temperature-sensitive hydrogel dressing loaded with nicotinamide mononucleotide accelerating wound healing in diabetic mice [ Biomed Pharmacother, 2023, 10.1016/j.biopha.2023.115431] | PubMed: 37688988 |
β-nicotinamide mononucleotide rescues the quality of aged oocyte and improves subsequent embryo development in pigs [ PLoS One, 2023, 18(10):e0291640] | PubMed: 37796824 |
DePARylation is critical for S phase progression and cell survival [ bioRxiv, 2023, 2023.07.31.551317] | PubMed: 37577639 |
DePARylation is critical for S phase progression and cell survival [ bioRxiv, 2023, 2023.07.31.551317] | PubMed: 37577639 |
Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation [ Cell Death Differ, 2022, 10.1038/s41418-022-00992-3] | PubMed: 35568718 |
Administration of nicotinamide mononucleotide improves oocyte quality of obese mice [ Cell Prolif, 2022, e13303] | PubMed: 35811338 |
DNA damage contributes to age-associated differences in SARS-CoV-2 infection [ Aging Cell, 2022, 21(12):e13729] | PubMed: 36254583 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。