Astilbin

製品コードS3932 バッチS393202

印刷

化学情報

Chemical Structure Synonyms Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H22O11
分子量 450.39 CAS No. 29838-67-3
Solubility (25°C)* 体外 DMSO 90 mg/mL (199.82 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
in vitro In vitro, astilbin inhibits Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibits Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions. Astilbin has been reported to possess multiple clinically relevant bioactivities, including antioxidant, anti-inflammatory, anti-arthritic, and anti-diabetic nephropathy properties. Nevertheless, the molecular mechanisms by which astilbin interacts with inflammatory processes are poorly understood. Astilbin not only inhibits T lymphocyte function in acute heart allograft rejection, but also inhibits migration and antigen presenting of dendritic cells (DCs)[1].
in vivo Astilbin is reported to reduce activation of both T and B cells in lupus-prone mice. It significantly inhibits inflammatory responses and keratinocyte over-proliferation in a mouse model of imiquimod (IMQ)-induced psoriasis[1]. Astilbin undergoes extensive biotransformation specifically due to enzyme catechol-O-methyl transferase. It gives rise to 3′-O-methylastilbin, a major metabolite of astilbin, which plays important role against the inhibition activated T lymphocytes. The pharmacokinetic parameters of astilbin followed by intragastric administration astilbin (40 mg/kg): Cmax=37.7±14.7 ng/mL, Tmax=25.8±34.3 min, t1/2=161.6±44.1 min[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 CD4+ T cells
濃度 0-100 μg/ml
反応時間 3 days
実験の流れ Cell viability is assessed using the Cell Counting Kit-8 (CCK8) assay at 3 days after induction of Th17 differentiation. The mean optical density (OD) of the three wells in each group is used to calculate the percentage of cell proliferation.
動物実験 動物モデル BALB/c mice (male, 18 to 20 g, 8 week-old)
投薬量 25 to 50 mg/kg
投与方法 orally administered

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ethanol extract from Astilbe chinensis inflorescence suppresses inflammation in macrophages and growth of oral pathogenic bacteria [ PLoS One, 2024, 19(7):e0306543] PubMed: 38959234

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。