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受注：045-509-1970 |
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化学情報
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
| 化学式 | C8H11ClFNO2S |
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| 分子量 | 239.69 | CAS No. | 30827-99-7 | |
| Solubility (25°C)* | 体外 | DMSO | 47 mg/mL (196.08 mM) | |
| Water | 47 mg/mL (196.08 mM) | |||
| Ethanol | 47 mg/mL (196.08 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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溶剤液（一定の濃度）を調合する
生物活性
| 製品説明 | AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor. |
|---|---|
| in vitro | AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. [1] AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. [2] AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern. [4] |
| in vivo | AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. [3] AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model. [4] |
| 特徴 | Broad spectrum, irreversible serine protease inhibitor. |
プロトコル(参考用のみ)
| 動物実験 | 動物モデル | Mice infected by a lethal T. Gondii |
|---|---|---|
| 投薬量 | ~76.8 mg/kg daily | |
| 投与方法 | i.p. |
参考
Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：
| Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK‒STAT pathway [ Acta Pharm Sin B, 2024, 14(6):2554-2566] | PubMed: 38828147 |
| Targeting Cancer Mitochondria by Inducing an Abnormal Mitochondrial Unfolded Protein Response Leads to Tumor Suppression [ Int J Med Sci, 2024, 21(7):1204-1212] | PubMed: 38818479 |
| Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cerebral ischemia/reperfusion injury [ Int J Biol Sci, 2023, 19(13):4327-4339] | PubMed: 37705748 |
| Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cerebral ischemia/reperfusion injury [ Int J Biol Sci, 2023, 19(13):4327-4339] | PubMed: 37705748 |
| Inhibition of signal peptidase complex expression affects the development and survival of Schistosoma japonicum [ Front Cell Infect Microbiol, 2023, 13:1136056] | PubMed: 36936776 |
| Inhibition of signal peptidase complex expression affects the development and survival of Schistosoma japonicum [ Front Cell Infect Microbiol, 2023, 13:1136056] | PubMed: 36936776 |
| Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts [ Int J Mol Sci, 2021, 22(7)3683] | PubMed: 33916165 |
| Evaluation of enzymatic proteoglycan loss and collagen degradation in human articular cartilage using ultrashort echo time-based biomarkers: A feasibility study [ NMR Biomed, 2021, e4664] | PubMed: 34904305 |
| Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents [ Front Cell Dev Biol, 2020, 8:269] | PubMed: 32500072 |
| Thapsigargin Promotes Colorectal Cancer Cell Migration Through Upregulation of lncRNA MALAT1 [ Oncol Rep, 2020, 43(4):1245-1255] | PubMed: 32323831 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。