受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C17H18N2 |
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分子量 | 250.34 | CAS No. | 49671-76-3 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 50 mg/mL (199.72 mM) | ||||||||
Ethanol | 12 mg/mL (47.93 mM) | ||||||||||
Water | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator. |
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in vitro | In L6 myotubes, ZLN005 increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity. While ZLN005 does not has the same effects in rat primary hepatocytes, which suggests cell type–specificity. [1] |
in vivo | ZLN005 (15 mg/kg, p.o.) produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice but not lean mice. [1] |
動物実験 | 動物モデル | Male C57BKS db/db and lean littermate C57BKS mice. |
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投薬量 | ~15 mg/kg | |
投与方法 | p.o. |
Data from [Data independently produced by , , Exp Cell Res, 2016, 345(1):25-36.]
Data from [Data independently produced by , , Endocrine, 2016, 53(2):443-52]
ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes [ Front Immunol, 2023, 14:1089905] | PubMed: 36820088 |
The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α [ Anim Nutr, 2022, 11:121-131] | PubMed: 36204284 |
The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α [ Anim Nutr, 2022, 11:121-131] | PubMed: 36204284 |
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis [ Biomed Pharmacother, 2021, 144:112331] | PubMed: 34673421 |
PGC-1ɑ Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity of PC12 Cells [ J Mol Neurosci, 2021, 10.1007/s12031-020-01775-6] | PubMed: 33515431 |
Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells [ Stem Cell Reports, 2020, S2213-6711(20)30418-5] | PubMed: 33186539 |
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers [ Cancers (Basel), 2020, 12(9)E2397] | PubMed: 32847042 |
Overexpression of Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α Protects Cardiomyocytes From Lipopolysaccharide-Induced Mitochondrial Damage and Apoptosis [ Inflammation, 2020, 10.1007/s10753-020-01255-4] | PubMed: 32529514 |
The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2. [ Protein Cell, 2019, 10(6):436-449] | PubMed: 30324491 |
Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning. [ J Pineal Res, 2019, 67(4):e12607] | PubMed: 31469445 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。