Pancuronium dibromide

製品コードS2497 バッチS249706

印刷

化学情報

Chemical Structure Synonyms Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C35H60N2O4.2Br
分子量 732.67 CAS No. 15500-66-0
Solubility (25°C)* 体外 DMSO 100 mg/mL (136.48 mM)
Water 100 mg/mL (136.48 mM)
Ethanol 100 mg/mL (136.48 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.
in vitro

Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. [1] Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria.  [2] Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat.[3]
in vivo

Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dose dogs by 82%. Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in low dose dogs by 40% and 55%. [4] Pancuronium limits cerebral hyperemia during prolonged seizures by attenuating increases in blood pressure as a result of elimination of skeletal muscle activity in newborn pigs. [5] Pancuronium results in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM  in tracheal smooth muscle strips from guinea-pigs.[6]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats [ bioRxiv, 2024, 2024.05.23.595327] PubMed: 38826205
NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction [ Biomedicines, 2022, 10(12)3056] PubMed: 36551811
One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats [ Elife, 2019, 8e45399] PubMed: 30900989
Viral Mimetic-Induced Inflammation Abolishes Q-Pathway, but Not S-Pathway, Respiratory Motor Plasticity in Adult Rats [ Front Physiol, 2019, 10:1039] PubMed: 31456699
Disruption of Neurorespiratory Control by Acute Inflammation, Neonatal Inflammation, and Perinatal Opioids [ Scholars' Bank, 2019, N/A] PubMed: N/A
IL-1 receptor activation undermines respiratory motor plasticity after systemic inflammation. [ J Appl Physiol (1985), 2018, 125(2):504-512] PubMed: 29565772
Deep Brain Stimulation with Simultaneous fMRI in Rodents [Younce JR, et al. J Vis Exp, 2014, (84):e51271] PubMed: 24561922

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。